Multiplex PCR theranostics of severe respiratory infections.

Scope of the problem Acute respiratory tract infection is the leading cause of hospitalization for infants and young children in developed countries, and a major determinant of death in developing countries. In 2002, lower respiratory tract infections accounted for approximately 4 million deaths worldwide and 7% of all deaths that year [1]. Therefore, there is a huge need for new diagnostic tools that enable the detection of a broad range of respiratory pathogens, especially those that are difficult or impossible to obtain by conventional culture methods.